![]() ![]() ![]() Studies support the importance of macrophages to initiate and maintain the inflammatory response, as well as a determinant of resolution of lung inflammation and repair. Key aspects of their biological response, including differentiation, phenotype, function, and cellular interactions, are determined in large part by the presence, severity, and chronicity of local inflammation. Macrophages are essential to innate immunity and host defense, playing a featured role in the lung and alveolar space. Experimental animal models of acute lung injury (ALI) reproduce key components of the injury and resolution phases of human ARDS and provide a methodology to explore mechanisms and potential new therapies. #Zotz strain seriesIn patients surviving the inflammatory and subsequent fibroproliferative stages, transition from injury to resolution and recovery is an active process dependent on a series of highly coordinated events regulated by the immune system. Fundamental to ARDS is the acute onset of lung inflammation as a part of the body's immune response to a variety of local and systemic stimuli. Leslie Renken can be reached at 686-3250 and Follow her on Twitter, and subscribe to her on / respiratory distress syndrome (ARDS) is a devastating disease with distinct pathological stages. An experienced artist, he works quickly and efficiently - for Kettleborough, the doors are just the right size to be fun. Though he only works a few hours each morning while it is still relatively cool, Kettleborough expects to finish by the end of next week. Poised to start the job last summer, Kettleborough was forced to put it off a year because of health issues. ![]() I could picture what he wanted right off the bat,” said Kettleborough. Kettleborough was asked to do the job last summer by his friend Mark Matuszak, general manager of the cemetery. “There are 17 mausoleums in the cemetery, and a lot of them have stone doors because the doors didn’t last over the years,” he said. He hopes the job will lead to paying jobs. #Zotz strain proThough Kettleborough is accustomed to making good money for his murals, he’s doing the work in Springdale Cemetery pro bono. He will have a show in August at Exhibit A Gallery in Peoria Heights. He splits his time between a home in Peoria and one in New Orleans and shows at galleries in both cities. Today Kettleborough doesn’t do as many murals as he once did, he’s still is a prolific painter. Not so much now, and that’s OK with me,” said Kettleborough, who stopped painting ceiling murals about 15 years ago because of the physical strain. “In the late 80s and early 90s, everybody wanted a mural in their home. Kettleborough did so well he was one of several artists interviewed for a 1999 article in Forbes magazine titled “Unstarving Artists.” A newspaper did an article on it and I got a lot of jobs out of it.” “He asked me to give a presentation, and I got a big job out of it in probably the most extravagant home in Naples,” said Kettleborough. A friend who worked as an interior designer helped Kettleborough get his first mural job in a Florida home. “I quit when I was 36 to go out on my own as an artist,” he said. A native of Mendota, Kettleborough taught art at Peoria High School for 15 years. Kettleborough, 71, has had a long career painting trompe l'oeil murals. ![]()
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